Identification of naturally occurring temperature-sensitive strains of influenza A virus and location of their genetic lesions.
Identifieur interne : 000189 ( 1957/Analysis ); précédent : 000188; suivant : 000190Identification of naturally occurring temperature-sensitive strains of influenza A virus and location of their genetic lesions.
Auteurs : Y M Zhang ; S F Tian ; J M ZhuSource :
- Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences [ 0253-5823 ] ; 1982.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Embryon de poulet, Flambées de maladies, Grippe humaine (génétique), Humains, Mutation, Nucléoprotéines (génétique), Protéines de la matrice virale, Protéines virales (génétique), Recombinaison génétique, Température, Test de complémentation, Virus de la grippe A (génétique), Virus de la grippe A (physiologie).
- MESH :
- génétique : Grippe humaine, Nucléoprotéines, Protéines virales, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- Animaux, Cellules cultivées, Embryon de poulet, Flambées de maladies, Humains, Mutation, Protéines de la matrice virale, Recombinaison génétique, Température, Test de complémentation.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Chick Embryo, Disease Outbreaks, Genetic Complementation Test, Humans, Influenza A virus (genetics), Influenza A virus (physiology), Influenza, Human (genetics), Mutation, Nucleoproteins (genetics), Recombination, Genetic, Temperature, Viral Matrix Proteins, Viral Proteins (genetics).
- MESH :
- chemical , genetics : Nucleoproteins, Viral Proteins.
- genetics : Influenza A virus, Influenza, Human.
- physiology : Influenza A virus.
- Animals, Cells, Cultured, Chick Embryo, Disease Outbreaks, Genetic Complementation Test, Humans, Mutation, Recombination, Genetic, Temperature, Viral Matrix Proteins.
Abstract
Influenza A viruses of different subtypes isolated in different years and from different parts of China were examined for temperature-sensitiveness (ts) in their early egg passages. The validity of ts character has been confirmed by the results of parallel tests in chick embryos and in cell cultures. From 12 strains of the old H1N1 subtype isolated between 1949 and 1957, no ts strain was detected. Two out of 6 strains of new H1N1 isolated after February 1979 were found to be ts. For the H3N2 subtype, only 8 out of 23 strains isolated between 1968 and 1978 were ts, but the proportion increased abruptly of 13 out of 15 strains isolated in 1979-1980. We also found 6 out of 16 strains of the H2N2 subtype to be ts. Two H2N2 and one H3N2 strains examined were found to be composed of mixed ts and ts+ particles. By recombination-complementation test against 7 standard ts strains of WSN virus with known genetic lesions, the ts lesions of the H3N2 strain Hong Kong/8/68 was located on the nucleoprotein gene, whereas that of the H1N1 strain Tianjin/78/77 was located on the matrix protein gene.
PubMed: 7100902
Affiliations:
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pubmed:7100902Le document en format XML
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Series B, Chemical, biological, agricultural, medical & earth sciences</title><idno type="ISSN">0253-5823</idno><imprint><date when="1982" type="published">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Chick Embryo</term><term>Disease Outbreaks</term><term>Genetic Complementation Test</term><term>Humans</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (physiology)</term><term>Influenza, Human (genetics)</term><term>Mutation</term><term>Nucleoproteins (genetics)</term><term>Recombination, Genetic</term><term>Temperature</term><term>Viral Matrix Proteins</term><term>Viral Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Embryon de poulet</term><term>Flambées de maladies</term><term>Grippe humaine (génétique)</term><term>Humains</term><term>Mutation</term><term>Nucléoprotéines (génétique)</term><term>Protéines de la matrice virale</term><term>Protéines virales (génétique)</term><term>Recombinaison génétique</term><term>Température</term><term>Test de complémentation</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nucleoproteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term><term>Nucléoprotéines</term><term>Protéines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Chick Embryo</term><term>Disease Outbreaks</term><term>Genetic Complementation Test</term><term>Humans</term><term>Mutation</term><term>Recombination, Genetic</term><term>Temperature</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Embryon de poulet</term><term>Flambées de maladies</term><term>Humains</term><term>Mutation</term><term>Protéines de la matrice virale</term><term>Recombinaison génétique</term><term>Température</term><term>Test de complémentation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza A viruses of different subtypes isolated in different years and from different parts of China were examined for temperature-sensitiveness (ts) in their early egg passages. The validity of ts character has been confirmed by the results of parallel tests in chick embryos and in cell cultures. From 12 strains of the old H1N1 subtype isolated between 1949 and 1957, no ts strain was detected. Two out of 6 strains of new H1N1 isolated after February 1979 were found to be ts. For the H3N2 subtype, only 8 out of 23 strains isolated between 1968 and 1978 were ts, but the proportion increased abruptly of 13 out of 15 strains isolated in 1979-1980. We also found 6 out of 16 strains of the H2N2 subtype to be ts. Two H2N2 and one H3N2 strains examined were found to be composed of mixed ts and ts+ particles. By recombination-complementation test against 7 standard ts strains of WSN virus with known genetic lesions, the ts lesions of the H3N2 strain Hong Kong/8/68 was located on the nucleoprotein gene, whereas that of the H1N1 strain Tianjin/78/77 was located on the matrix protein gene.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Tian, S F" sort="Tian, S F" uniqKey="Tian S" first="S F" last="Tian">S F Tian</name><name sortKey="Zhang, Y M" sort="Zhang, Y M" uniqKey="Zhang Y" first="Y M" last="Zhang">Y M Zhang</name><name sortKey="Zhu, J M" sort="Zhu, J M" uniqKey="Zhu J" first="J M" last="Zhu">J M Zhu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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